Realistic and discriminative in vitro release in pH 6.8 [B] physiological bicarbonate buffer compared to [A] compendial phosphate buffer for enteric coated formulations
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چکیده
and discriminative in vitro release in pH 6.8 [B] physiological bicarbonate buffer compared to [A] compendial phosphate buffer for enteric coated formulations
منابع مشابه
In vitro dissolution of proton-pump inhibitor products intended for paediatric and geriatric use in physiological bicarbonate buffer.
Proton-pump inhibitor (PPI) products based on enteric coated multiparticulates are design to meet the needs of patients who cannot swallow tablets such as children and older adults. Enteric coated PPI preparations exhibit delays in in vivo absorption and onset of antisecretory effects, which is not reflected by the rapid in vitro dissolution in compendial pH 6.8 phosphate buffer commonly used f...
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تاریخ انتشار 2010